Selected Publications from the Lab:

Marcinkiewicz K, Scotland KB, Boorjian SA, Nilsson EM, Persson JL, Abrahamsson PA, Allegrucci C, Hughes IA, Gudas LJ, Mongan NP. (2011) The androgen receptor and stem cell pathways in prostate and bladder cancers (Review). Int J Oncol. 2011 Sep 28. doi: 10.3892/ijo.2011.1212. [Epub ahead of print]

Fu L, Wang G, Shevchuk MM, Nanus DM, Gudas LJ. (2011) Generation of a Mouse Model of Von Hippel-Lindau Kidney Disease Leading to Renal Cancers by Expression of a Constitutively Active Mutant of HIF1{alpha}. Cancer Res. 2011 Sep 9. [Epub ahead of print]

Laursen, K.B., Wong, P.-M., and Gudas, L.J.(2011) Epigenetic Regulation by RAR? Maintains Ligand Independent Transcriptional Activity.Nucleic Acids Res., 2011 Sep 12. [Epub ahead of print]

Larsson, R., Mongan, N.P., Johansson, M., Shcherbina, L., Abrahamsson, P.-A., Gudas, L.J., Sterner, O., and Persson, J.L. (2011) Clinical trials update and novel therapeutic approaches for metastatic prostate cancer. Curr Med Chem. 2011 Aug 25. [Epub ahead of print].

Gudas, L.J. (2011) Emerging roles for retinoids in regeneration and differentiation in normal and disease states. Biochim Biophys Acta 2011 Aug 7 [Epub ahead of print]

Rezende N, Lee MY, Monette S, Mark W, Lu A, Gudas LJ. (2011) Rex1 (Zfp42) Null Mice Show Impaired Testicular Function, Abnormal Testis Morphology, and Aberrant Gene Expression. Dev Biol. 2011;356(2):370-82.

Kauffman, E.C., Robinson, B.D., Downes, M., Powell, L., Lee, M.M., Scherr, D.S., Gudas, L.J. and Mongan, N.P. (2010) Role of androgen receptor lysine-demethylase coregulators, LSD1 and JMJD2A, in human bladder cancer. Mol Carcinog. 2011 Mar 11. doi: 10.1002/mc.20758.

Kashyap V, Gudas LJ, Brenet F, Funk P, Viale A, Scandura JM. Epigenomic reorganization of the clustered hox genes in embryonic stem cells induced by retinoic acid. J Biol Chem. 2011 Feb 4;286(5):3250-60.

Tang XH, Gudas LJ. Retinoids, Retinoic Acid Receptors, and Cancer. Annu Rev Pathol. 2011 Feb 28;6:345-364.

Reynertson KA, Charlson ME, Gudas LJ. Induction of murine embryonic stem cell differentiation by medicinal plant extracts. Exp Cell Res. 2010;317(1):82-93.

Amat R, Gudas LJ. RAR? is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells. J Cell Physiol. 2010;226(2):293-8.

Gudas LJ, Wagner JA. Retinoids regulate stem cell differentiation. J Cell Physiol. 2010;226(2):322-30.

Wang R, Wang G, Ricard MJ, Ferris B, Strulovici-Barel Y, Salit J, Hackett NR, Gudas LJ, Crystal RG. Smoking-induced Up-regulation of AKR1B10 Expression in the Airway Epithelium of Healthy Individuals. Chest. 2010:138(6):1402-10.

Lee MY, Lu A, Gudas LJ. Transcriptional regulation of Rex1 (zfp42) in normal prostate epithelial cells and prostate cancer cells. J Cell Physiol. 2010 July;224(1):17-27.

Kashyap V, Gudas LJ. Epigenetic regulatory mechanisms distinguish retinoic acid mediated transcriptional responses in stem cells and fibroblasts. J Biol Chem. 2010 May 7;285(19):14534-48.

Wang G, Badylak SF, Heber-Katz E, Braunhut SJ, Gudas LJ. The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice. Regen Med. 2010 Mar;5(2):201-20. 

David KA, Mongan NP, Smith C, Gudas LJ, Nanus DM. Phase I trial of ATRA-IV and depakote in patients with advanced solid tumor malignancies. Cancer Biol Ther. 2010 May 8;9(9). 

Agrawal V, Johnson SA, Reing J, Zhang L, Tottey S, Wang G, Hirschi KK, Braunhut S, Gudas LJ, Badylak SF. Epimorphic regeneration approach to tissue replacement in adult mammals. Proc Natl Acad Sci U S A. 2009 Feb 23:107(8):3351-5.

Tang XH, Albert M, Scognamiglio T, Gudas LJ. A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Cancer Prev Res (Phila Pa). 2009 Dec;2(12):1100-10.

Liu L, Tang XH, Scognamiglio T, Gudas LJ. .Oral carcinogenesis induced by 4-nitroquinoline 1-oxide in lecithin:retinol acyltransferase gene knockout mice. J Nutr Biochem. 2010 Oct;21(10):975-82. 

Scotland KB, Chen S, Sylvester R, Gudas LJ. Analysis of Rex1 (zfp42) function in embrionic stem cell differentiation. Dev Dyn 2009 Jul 17;238(8):1863-1877.

Touma SE, Perner S, Rubin MA, Nanus DM, Gudas LJ. Retinoid metabolism and ALDH1A2 (RALDH2) expression are altered in the transgenic adenocarcinoma mouse prostate model. Biochem Pharmacol 2009 Biochem Pharmacol. 2009 Nov 1;78(9):1127-38.

Liu L, Derguini F, Gudas LJ. Metabolism and regulation of gene expression by 4-oxoretinol versus all-trans retinoic acid in normal human mammary epithelial cells. J Cell Physiol. 2009 Sep;220(3):771-9.

Kashyap V, Rezende NC, Scotland KB, Shaffer SM, Persson JL, Gudas LJ, Mongan NP. Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the Nanog, OCT4 and SOX2 pluripotency transcription factors with Polycomb Repressive Complexes and Stem Cell micro-RNAs. Stem Cells Dev. 2009 Sep;18(7):1093-108.

Tang XH, Su D, Albert M, Scognamiglio T, Gudas LJ. Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen. Cancer Biol Ther. 2009 Jul 6;8(13). [Epub ahead of print]

Schupp, M., Lefterova, M.I., Janke, J., Leither, K., Cristancho, A.G., Mullican, S.E., Qatanani, M., Szwergold, N., Steger, D.J., Curtin, J.C., Kim, R.J., Suh, M., Albert, M.R., Engeli, S., Gudas, L.J., Lazar, M.A. (2009) Retinol saturase promotes adipogenesis and is downregulated in obesity. Proc Natl Acad Sci USA, Jan 27;106(4):1105-10.

Fernandez, C. and Gudas, L.J. (2009) The Truncated Hoxa1 Protein Interacts with Hoxa1 and Pbx1 in Stem Cells.  J. Cell. Biochem. Feb 15;106(3):427-43.

Cai, K. and Gudas, L.J. (2009) Retinoic acid receptors and GATA transcription factors activate the transcription of the human lecithin:retinol acyltransferase gene.  Int. J. Biochem. Cell Biol; 41(3):546:53.

Brennen, E.P., Tang, X.H., Stewart-Akers, A.M., Gudas, L.J., and Badylak, S.F. (2008) Chemoattractant activity of degradation products of fetal and adult skin extracellular matrix for keratinocyte progenitor cells.  J. Tissue Eng. Regen. Med.  Dec;2(8):491-8.

Tavares, T.S., Nanus, D., Yang, X.J., and Gudas, L.J. (2008) Gene Microarray Analysis of Human Renal Cell Carcinoma: the Effects of HDAC Inhibition and Retinoid Treatment.  Cancer Biol. Ther.  Oct 9;7(10):1607-18.

Liu, L., Tang, X.-H., and Gudas, L.J. (2008) Homeostasis of Retinol in Lecithin:retinol Acyltransferase Gene Knockout Mice Fed a High Retinol Diet. Biochem. Pharmacol. 75(12):2316-2324.

Martinez-Ceballos, E. and Gudas, L.J. (2008) Hoxa1 is Required for the Retinoic Acid-induced Differentiation of Embryonic Stem Cells into Neurons. J. Neurosci. Res. 86(13):2809-2819.

Langton, S. and Gudas, L.J. (2008) CYP26A1 Knockout Embryonic Stem Cells Exhibit Reduced Differentiation and Growth Arrest in Response to Retinoic Acid. Dev. Biol.  315(2):331-354.

Lane, M.A., Xu, J., Wilen, E.W., Sylvester, R., Derguini, F., and Gudas, L.J. (2008) LIF removal increases CRABPI and CRABPII transcripts in embryonic stem cells cultured in retinol or 4-oxoretinol.  Mol. Cell. Endocrinol.  280:63-74.

Xu, J., Sylvester, R., Tighe, A.P., Chen, S., and Gudas, L.J.  (2008) Transcriptional Activation of the Suppressor of Cytokine Signaling–3 (SOCS-3) Gene via STAT3 is Enhanced in F9 Rex1 (Zfp-42) Knockout Teratocarcinoma Stem Cells Relative to Wild Type Cells. J. Mol. Biol. 377(1):28-46.

Su, D. and Gudas, L.J. (2008) Retinoic Acid Receptor gamma Activates Receptor Tyrosine Kinase Tie1 Gene Transcription through Transcription Factor GATA4 in F9 Teratocarcinoma Stem Cells.  Exp. Hematol.  36(5):624-641.

Zhuang, Y. and Gudas, L.J. (2008) Overexpression of COUP-TF1 in murine embryonic stem cells reduces retinoic acid-associated growth arrest and increases extraembryonic endoderm gene expression.  Differentiation. 76(7):760-771.

Su, D. and Gudas, L.J. (2008) Gene Expression Profiling Elucidates a Specific Role for RARg in the Retinoic Acid Induced Differentiation of F9 Teratocarcinoma Stem Cells.  Biochem. Pharmacol.  75(5):1129-1160.

Tang, X.-H., Vivero, M., and Gudas, L.J. (2008) Overexpression of CRABPI in suprabasal keratinocytes enhances the proliferation of epidermal basal keratinocytes in mouse skin topically treated with all-trans retinoic acid.  Exp. Cell Res. 2008 314:38-51.

Gillespie, R.F. and Gudas, L.J. (2007) RAR isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic acid response elements. J. Biol. Chem. 282(46):33421-34.

Mongan, N.P. and Gudas, L.J. (2007) Diverse actions of retinoid receptors in cancer prevention and treatment. Differentiation.  75(9):853-70. Epub 2007 Jul 18.

Gillespie, R.F. and Gudas, L.J. (2007) Retinoid Regulated Association of Transcriptional Coregulators and the Polycomb Group Protein SUZ12 with the Retinoic Acid Response Elements of Hoxa1, RARb₂, and Cyp26A1 in F9 Embryonal Carcinoma Cells.  J. Mol. Biol.  372(2):298-316.

Boorjian, S.A., Milowski, M.I., Kaplan, J., Albert, M., Cobham, M., Coll, D.M., Mongan, N.P., Shelton, G., Petrylak, D., Gudas, L.J., and Nanus, D.M. (2007) Phase I/II Trial of Interferon a2b and Liposome-Encapsulated All-Trans Retinoic Acid in the Treatment of Patients with Advanced Renal Cell Carcinoma.  J. Immunother.  30(6):655-62.

Tang, X.-H., Suh, M.-J., Li, R., and Gudas, L.J. (2007) Cell Proliferation Inhibition and Alterations in Retinol Esterification Induced by Phytanic Acid and Docosahexaenoic Acid. J. Lipid Res.  48(1):165-76.

Gudas, L.J. (2006) Stem Cells, Differentiation and Cancer: Mentors, Colleagues and Academic Administration.  Cancer Biol. Ther. 5(9):1244-6.

Mongan, N.P., Martin, K.M., and Gudas, L.J. (2006) The Putative Human Stem Cell Marker, Rex-1 (Zfp42): Structural Classification And Expression In Normal Human Epithelial And Carcinoma Cell Cultures. Mol. Carcinog. 45(12):887-900.

Raman JD, Mongan NP, Liu L, Tickoo SK, Nanus DM, Scherr DS, Gudas LJ. (2006) Decreased expression of the human stem cell marker, rex-1 (zfp-42), in renal cell carcinoma. Carcinogenesis. 27(3):499-507.

Raman JD, Mongan NP, Tickoo SK, Boorjian SA, Scherr DS, Gudas LJ. Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder. Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8570-6.

Liu, L., Tang, X.-H., and Gudas, L.J. Retinol Levels and Gene Expression in Wild Type and Lecithin:retinol Acyltransferase Gene Knockout Mice Fed a High Retinol Diet. J. Biol. Chem. 2005 Dec 2;280(48):40226-34. Epub 2005 Sep 20.

Liu L, Gudas LJ. Disruption of the lecithin:Retinol acyltransferase gene makes mice more susceptible to vitamin A deficiency. J Biol Chem. 2005 Dec 2;280(48):40226-34. Epub 2005 Sep 20.

Touma SE, Goldberg JS, Moench P, Guo X, Tickoo SK, Gudas LJ, Nanus DM. Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model. Clin Cancer Res. 2005 May 1;11(9):3558-66.

Mongan NP, Gudas LJ. Valproic acid, in combination with all-trans retinoic acid and 5-aza-2'-deoxycytidine, restores expression of silenced RARbeta2 in breast cancer cells. Mol Cancer Ther. 2005 Mar;4(3):477-86.

Boorjian S, Scherr DS, Mongan NP, Zhuang Y, Nanus DM, Gudas LJ. Retinoid receptor mRNA expression profiles in human bladder cancer specimens.  Int J Oncol. 2005 Apr;26(4):1041-8.

Martinez-Ceballos, E., Chambon, P., and Gudas, L.J. Differences in gene expression between wild type and Hoxa1 knockout embryonic stem cells after retinoic acid treatment or LIF removal. J. Biol. Chem.  280(16):16484-98, 2005

Boorjian S, Ugras S, Mongan NP, Gudas LJ, You X, Tickoo SK, Scherr DS.  Androgen receptor expression is inversely correlated with pathologic tumor stage in bladder cancer. Urology. 2004 Aug;64(2):383-8.

Sharif KA, Baker H, Gudas LJ.  Differential regulation of laminin b1 transgene expression in the neonatal and adult mouse brain.  Neuroscience. 2004;126(4):967-78.

Boorjian S, Tickoo SK, Mongan NP, Yu H, Bok D, Rando RR, Nanus DM, Scherr DS, Gudas LJ.  Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer.  Clin Cancer Res. 2004 May 15;10(10):3429-37.

Li R, Faria TN, Boehm M, Nabel EG, Gudas LJ.  Retinoic acid causes cell growth arrest and an increase in p27 in F9 wild type but not in F9 retinoic acid receptor beta2 knockout cells.  Exp Cell Res. 2004 294(1):290-300.

Tang XH, Knudsen B, Bemis D, Tickoo S, Gudas LJ.  Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice.  Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):301-13.

Tighe AP, Gudas LJ. Retinoic acid inhibits leukemia inhibitory factor signaling pathways in mouse embryonic stem cells.  J Cell Physiol. 2004 Feb;198(2):223-9.

Zhuang Y, Faria TN, Chambon P, Gudas LJ:  Identification and Characterization of Retinoic Acid Receptor beta(2) Target Genes in F9 Teratocarcinoma Cells. Mol Cancer Res. 2003 Jun;1(8):619-30.

Mohn D, Chen SW, Dias DC, Weinstein DC, Dyer MA, Sahr K, Ducker CE, Zahradka E, Keller G, Zaret KS, Gudas LJ, Baron MH: Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos.  Dev Dyn. 2003 Mar;226(3):446-59.

James R. Thompson and Lorraine J. Gudas: Retinoic acid induces parietal endoderm but not primitive endoderm and visceral endoderm differentiation in F9 teratocarcinoma stem cells with a targeted deletion of the Rex-1 (Zfp-42) gene.  Molecular and Cellular Endocrinology 2002 Sep 30;195(1-2):119-33.

Jonathan S. Goldberg, Manuel Vargas, Alyssa S. Rosmarin, Matthew I. Milowsky, Nicholas Papanicoloau, Lorraine J. Gudas, Gary Shelton, Kevie Feit, Daniel Petrylak, David M. Nanus: Phase I trial of interferon ∞2b and liposome-encapsulated all-trans retinoic acid in the treatment of patients with advanced renal cell carcinoma. Cancer  2002 Sep 15;95(6):1220-7.

Danyang Huang, Siming W. Chen, Lorraine J. Gudas: Analysis of Two Distinct Retinoic Response Elements in the Homeobox Gene Hoxb1 in Transgenic Mice.  Developmental Dynamics 2002 Mar;223(3):353-70.

Guo, X., Knudsen, B.S., Peehl, D.M., Ruiz, A., Bok, D., Rando, R.R., Rhim, J.S., Nanus, D.M., Gudas, L.J.: Retinol Metabolism and Lecithin: Retinol Acyltransferase Levels Are Reduced In Cultured Human Prostate Cancer Cells And Tissue Specimens.  Cancer Research 2002 Mar 15;62(6):1654-61.

Sharif, K.A., Li, C., Gudas, L.J.: cis-acting DNA regulatory elements, including the retinoic acid response element, are required for tissue specific laminin B1 promoter/lacZ expression in transgenic mice.  Mechanisms of Development 2001 May;103(1-2):13-25.

Gao, X., Ruiz, A., Rando, R. Bok, D., Gudas, L.J.: Esterfication of all-trans-retinol in normal human epithelial cell strains and carcinoma lines from oral cavity, skin and breast: reduced expression of lecithin:retinal acyltransferase in carcinoma lines. Carcinogenesis 2000 21(11):1925-1933.

Faria, T.N., Mendelsohn, C., Chambon, P., and Gudas, L.J.: The Targeted Disruption of Both Alleles of RARb2 in F9 Cells Results in the Loss of Retinoid Acid-Associated Growth Arrest. J. Biol. Chem. 1999 274: 26783-26788.

Lane, M.A., Chen, A.C., Roman, S.D., Derguini, F., and Gudas, L.J.: Removal of LIF (Leukemia Inhibitory Factor) Results in Increased Vitamin A (Retinol) Metabolism to 4-Oxoretinol in Embryonic Stem Cells. Proc. Natl. Acad. Sci. 1999 Nov 9;96(23):13524-9.

Guo, X. and Gudas, L.J.: Metabolism of All-Trans Retinol in normal human cell strains and squamous cell carcinoma lines from the oral cavity and skin: Reduced esterification of retinol in SCC lines. Cancer Research 1998 58:166-176.

Other Publications...