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Wang R, Wang G, Ricard MJ, Ferris B, Strulovici-Barel Y, Salit J, Hackett NR, Gudas LJ, Crystal RG. (2010) Smoking-induced Up-regulation of AKR1B10 Expression in the Airway Epithelium of Healthy Individuals. Chest. 2010 Aug 12. [Epub ahead of print].
Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R. (2010) Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal. 2010 Apr 18. [Epub ahead of print] PMID: 20406683.
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Tian Y, Bassit B, Chau D, Li YM. An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production
Nat Struct Mol Biol. 2010 Feb;17(2):151-8.
Charles N, Ozawa T, Squatrito M, Bleau AM, Brennan CW, Hambardzumyan D, Holland EC. Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells.
Cell Stem Cell. 2010 Feb 5;6(2):141-52.
Rotolo JA, Mesicek J, Maj J, Truman JP, Haimovitz-Friedman A, Kolesnick R, Fuks Z. Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.
Cancer Res. 2010 Feb 1;70(3):957-67.
Tresguerres M, Parks SK, Salazar E, Levin LR, Goss GG, Buck J. Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis.
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2009
Shelton CC, Zhu L, Chau D, Yang L, Wang R, Djaballah H, Zheng H, Li YM. Modulation of gamma-secretase specificity using small molecule allosteric inhibitors. (2009) Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20228-33.
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Yang G., Yin Y.I., Shelton C.C., Ouerfelli O., and Li Y.M. (2009) Strereo-controlled synthesis of novel photoreactive gamma-secretase inhibitors. Bioorg Med Chem Lett, 19(3): 922-925.
Placanica L., Tarassishin L., Yang G., Peethumnongsin E., Kim S.H., Zheng H., Sisodia S.S., and Li Y.M. (2009) Pen2 and Presenilin-1 Modulate the Dynamic Equilibrium of Presenilin-1 and Presenilin-2{gamma}-Secretase complexes. J Bio Chem;284(5):2967-2977.
Meng R.D., Shelton C.C., Li Y.M., Qin L.X., Notterman D., Paty P.B., and Schwartz G.K. (2009) Gamma-secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res; 69:573-582.
Xu X., Kanda V.A., Choi E., Panaghie G., Roepke T.K., Gaeta S.A., Christini D.J., Lerner D.J., Abbott G.W. (2009) Mink-dependent internnalization of the IKs potassium channel. Cardiovascular Res. Jun 1;82(3);430-8.
Escobar-Alvarez S., Goldgur Y., Yang G., Ouerfelli O., Li Y., Scheinberg D.A. (2009) Structure and activity of human mitochondrial peptide deformylase, a novel cancer target. J Mol Biol Apr 17;387(5):1211-28.
Acin-Perez R., Salazar E., Kamenetsky M, Buck J., Levin L.R., and Manfredi G. (2009) Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metabol Mar;9(3):265-76.
Bogulavsky J.J., Gregus A.M., Kim P.T., Costa A.C., Rajadhyaksha A.M., Inturrisi C.E. (2009) Deletion of the glutamate receptor 5 subunit of kainate receptors affects the development affects the development of morphine tolerance. J Pharmacol Exp Ther Feb;328(2):579-87.
Tresguerres M, Parks SK, Salazar E, Levin LR, Goss GG, Buck J. (2010) Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis.
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):442-7. PMID: 20018667.
2008
Gomez-Nunez M., Haro K.J., Dao T., Chau D., Won A., Escobar-Alvarez S., Zakhaleva V., Korontsvit T., Gin D.Y., Schienberg D.A. (2008) Non-natural and photo-reactive amino acids as biochemical probes of immune function. PLoS ONE 3(12);e3938.
Panaghie G., Purtell K, Tai K.K., Abbott G.W.(2008) Voltage-dependent C-type inactivation in a constitutively open K+ channel. Biophys J;95:2759-78.
Xu Q., Garraway S.M., Weyerbacher A.R., Shin S.J., Inturrisi C.E. (2008) Activation of the neuronal extracellular signal-regulated kinase 2 in the spinal cord dorsal horn is required for complete Freund's adjuvant-induced pain hypersensitivity. J Neurosci; 28(52):14087-96.
Villa C.H., McDevitt M.R., Escorcia F.E., Rey D.A., Bergkvist M., Batt C.A., Scheinberg D.A. (2008) Synthesis and Biodistribution of Oligonucleotide-Functionalized, Tumor-Targetable Carbon Nanotubes. Nano Lett Dec;8(12);4221-8.
Farrell J., Ramos L., Tresguerres M., Kamenetsky M., Levin L.R., and Buck J. (2008) Somatic 'Soluble' adenylyn cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'Knockout' mice. PLoS ONE; 3(9):e3251.
Ramos L.S., Zippin J.H., Kamentsky M., Buck J., Levin L.R. (2008) Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J Gen Physiol Sep;132(3):329-38.
Xu J., Sylvester R., Tighe A.P., Chen S., Gudas L.J. (2008) Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wil-type cells. J Mol Biol, 377:28-46.
Guasparri, I., Bubman, D., and Cesarman, E. (2008) EBV LMP2A affects LMP1-mediated NF-kappaB signaling and survival of lymphoma cells by regulating TRAF2 expression. Blood, 111:3813-3820.
Nuriel, T., Deeb, R.S., Hajjar, D.P., and Gross, S.S. (2008) Protein 3-nitrotyrosine in complex biological samples: quantification by high-pressure liquid chromatography/electrochemical detection and emergence of proteomic approaches for unbiased identification of modification sites. Methods Enzymol, 441:1-17.
Cheng, H.T., Suzuki, M., Hegarty, D.M., Xu, Q., Weyerbacher, A.R., South, S.M., Ohata, M., and Inturrisi, C.E. (2008) Inflammatory pain-induced signaling events following a conditional deletion of the N-methyl-d-aspartate receptor in spinal cord dorsal horn. Neuroscience Aug 26;155(3):948-58.
Tatapudy, S., Bruening, S., Gleason, G., and Toth, M. (2008) Validation and use of a computer-assisted counting procedure to quantify BrdU-labeled proliferating cells in the early postnatal mouse hippocampus. J Neurosci Methods Jul 30;172(2);173-7..
Abbott, G.W., Gordon, E., and Davison, J. (2008) Expanding roles of Aboriginal health workers in the primary care setting: seeking recognition. Contemp Nurse, 27:157-164.
Zupan B., and Toth M., (2008) Inactivation of the maternal fragile X gene results in sensitization of GABA receptor function in the offspring. J Pharmacol Exp ther. Dec;327(3):820-6.
Pratilas CA, Hanrahan AJ, Halilovic E, Persaud Y, Soh J, Chitale D, Shigematsu H, Yamamoto H, Sawai A, Janakiraman M, Taylor BS, Pao W, Toyooka S, Ladanyi M, Gazdar A, Rosen N, Solit DB. Genetic predictors of MEK dependence in non-small cell lung cancer. Cancer Res. 2008 Nov 15;68(22):9375-83.
Zupan, B. and Toth, M. (2008) Wild-Type Male Offspring of fmr-1(+/-) Mothers Exhibit Characteristics of the Fragile X Phenotype. Neuropsychopharmacology Oct;33(11):2667-75.
Gordon, E., Panaghie, G., Deng, L., Bee, K. J., Roepke, T. K., Krogh-Madsen, T., Christini, D. J., Ostrer, H., Basson, C. T., Chung, W., and Abbott, G. W. (2008) A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance. Cardiovasc Res, 77:98-106.
Su, D. and Gudas, L. J. (2008) Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells. Biochem Pharmacol, 75:1129-1160.
Taldone T., Gozman A.,Maharaj R., Chiosis G. (2008) Targeting Hsp90: smallmolecule inhibitors and their clinical development. Curr Opin Pharmacol Aug;8(4):370-4.
Langton, S. and Gudas, L. J. (2008) CYP26A1 knockout embryonic stem cells exhibit reduced differentiation and growth arrest in response to retinoic acid. Dev Biol, 315:331-354.
Rotolo, J. A., Maj, J. G., Feldman, R., Ren, D., Haimovitz-Friedman, A., Cordon-Cardo, C., Cheng, E. H., Kolesnick, R., and Fuks, Z. (2008) Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. Int J Radiat Oncol Biol Phys, 70:804-815.
Platholi, J., Heerdt, P. M., Lim Tung, H. Y., and Hemmings, H. C., Jr. (2008) Activation of brain protein phosphatase-1(I) following cardiac arrest and resuscitation involving an interaction with 14-3-3gamma. J Neurochem. 105(5):2029-38.
Zhang, T. T., Platholi, J., Heerdt, P. M., Hemmings, H. C., Jr., and Tung, H. Y. (2008) Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation. Metab Brain Dis, 23:95-104.
Su, D. and Gudas, L. J. (2008) Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells. Exp Hematol, 36:624-641.
Young J.J., Mehdi A., Stohl L.L., Levin L.R., Buck J., Wagner J.A., Stessin A. (2008) "Soluble" adenylyl cyclase-generated cyclic adenosine monophosphate promotes fast migration in PC12 cells. J Neurosci Res Jan;86(1):188-24.
2007
Nolan, D. J., Ciarrocchi, A., Mellick, A. S., Jaggi, J. S., Bambino, K., Gupta, S., Heikamp, E., McDevitt, M. R., Scheinberg, D. A., Benezra, R., and Mittal, V. (2007) Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes Dev, 21:1546-1558.
McDevitt, M. R., Chattopadhyay, D., Jaggi, J. S., Finn, R. D., Zanzonico, P. B., Villa, C., Rey, D., Mendenhall, J., Batt, C. A., Njardarson, J. T., and Scheinberg, D. A. (2007) PET imaging of soluble yttrium-86-labeled carbon nanotubes in mice. PLoS ONE, 2:e907.
Gillespie, R. F. and Gudas, L. J. (2007) Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements. J Biol Chem, 282:33421-33434.
Gillespie, R. F. and Gudas, L. J. (2007) Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells. J Mol Biol, 372:298-316.
Bubman, D., Guasparri, I., and Cesarman, E. (2007) Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigen. Oncogene, 26:4979-4986.
Choi, E. and Abbott, G. W. (2007) The MiRP2-Kv3.4 potassium channel: muscling in on Alzheimer's disease. Mol Pharmacol, 72:499-501.
Antczak, C., Shum, D., Escobar, S., Bassit, B., Kim, E., Seshan, V. E., Wu, N., Yang, G., Ouerfelli, O., Li, Y. M., Scheinberg, D. A., and Djaballah, H. (2007) High-throughput identification of inhibitors of human mitochondrial peptide deformylase. J Biomol Screen, 12:521-535.
Escorcia, F. E., McDevitt, M. R., Villa, C. H., and Scheinberg, D. A. (2007) Targeted nanomaterials for radiotherapy. Nanomed, 2:805-815.
Abbott, P., Gordon, E., and Davison, J. (2007) Expanding roles of Aboriginal health workers in the primary care setting: seeking recognition. Contemp Nurse, 26:66-73.
Garraway, S. M., Xu, Q., and Inturrisi, C. E. (2007) Design and evaluation of small interfering RNAs that target expression of the N-methyl-D-aspartate receptor NR1 subunit gene in the spinal cord dorsal horn. J Pharmacol Exp Ther, 322:982-988.
Jaggi, J. S., Carrasquillo, J. A., Seshan, S. V., Zanzonico, P., Henke, E., Nagel, A., Schwartz, J., Beattie, B., Kappel, B. J., Chattopadhyay, D., Xiao, J., Sgouros, G., Larson, S. M., and Scheinberg, D. A. (2007) Improved tumor imaging and therapy via i.v. IgG-mediated time-sequential modulation of neonatal Fc receptor. J Clin Invest, 117:2422-2430.
McDevitt, M. R., Chattopadhyay, D., Kappel, B. J., Jaggi, J. S., Schiffman, S. R., Antczak, C., Njardarson, J. T., Brentjens, R., and Scheinberg, D. A. (2007) Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes. J Nucl Med, 48: 1180-1189.
Singh Jaggi, J., Henke, E., Seshan, S. V., Kappel, B. J., Chattopadhyay, D., May, C., McDevitt, M. R., Nolan, D., Mittal, V., Benezra, R., and Scheinberg, D. A. (2007) Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization. PLoS ONE, 2:e267.
Sofou, S., Kappel, B. J., Jaggi, J. S., McDevitt, M. R., Scheinberg, D. A., and Sgouros, G. (2007) Enhanced retention of the alpha-particle-emitting daughters of Actinium-225 by liposome carriers. Bioconjug Chem, 18:2061-2067.
Angeles, A. R., Dorn, D. C., Kou, C. A., Moore, M. A., and Danishefsky, S. J. (2007) Total synthesis of peribysin E necessitates revision of the assignment of its absolute configuration. Angew Chem Int Ed Engl, 46:1451-1454.
Lahiri, S., Lee, H., Mesicek, J., Fuks, Z., Haimovitz-Friedman, A., Kolesnick, R. N., and Futerman, A. H. (2007) Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett, 581:5289-5294.
Paige, J. S. and Jaffrey, S. R. (2007) Pharmacologic manipulation of nitric oxide signaling: targeting NOS dimerization and protein-protein interactions. Curr Top Med Chem, 7:97-114.
Panaghie, G. and Abbott, G. W. (2007) The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes. J Gen Physiol, 129:121-133.
Vetrivel, K. S., Gong, P., Bowen, J. W., Cheng, H., Chen, Y., Carter, M., Nguyen, P. D., Placanica, L., Wieland, F. T., Li, Y. M., Kounnas, M. Z., and Thinakaran, G. (2007) Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism. Mol Neurodegener, 2:4.
Bullock, S. A., Platholi, J., Gjyrezi, A., Heerdt, P. M., Tung, H. Y., and Hemmings, H. C., Jr. (2007) Differential regulation of protein phosphatase-1(I) by neurabin. Biochem Biophys Res Commun, 358:140-144.
Derakhshan, B., Wille, P. C., and Gross, S. S. (2007) Unbiased identification of cysteine S-nitrosylation sites on proteins. Nat Protoc, 2:1685-1691.
Shang, S., Iwadare, H., Macks, D. E., Ambrosini, L. M., and Tan, D. S. (2007) A unified synthetic approach to polyketides having both skeletal and stereochemical diversity. Org Lett, 9:1895-1898.
Young, J.J.*, Mehdi, A.*, Stohl, L., Levin, L.R., Buck, J., Wagner, J.A., and Stessin A.M. (2007). 'Soluble' adenylyl cyclase-generated cyclic AMP promotes fast migration in PC12 cells. J. Neurosci. Res. 86:118-124.
Yang T., Chan N.Y., and Sauve A.A. (2007) Syntheses of nicotinamide ribosideand derivatives: effective agents for increasing nicotinamide adenine dinucleotide concentrations in mammalian cells. J Med Chem;50(26):6458-6461.
Broadbelt, N.V., Stahl P.J., Chen J., Mizrahi M., Lal A., Bozkurt A., Poppas D.P., Felsen D. (2007) Early upregulation of iNOS mRNA expression and increase in NO metabolites in pressurized renal epithelial cells. Am J Physiol Renal Physiol Dec;293(6):F1877-88.
2006
Kamenetsky, M., Middelhaufe, S. Bank, E.M., Levin, L.R., Buck, J., and Steegborn, C. (2006). Molecular details of cAMP generation in mammalian cells: A tale of two systems. J. Mol. Biol. 362:623-629.
Bruening S., Oh E., Hetzenauer A., Escobar-Alvarez S., Westphalen R.I., Hemmings H.C. Jr, Singewald N., Shippenberg T., and Toth M. (2006) The anxiety-like phenotype of 5-HT receptor null mice is associated with genetic background-specific perturbations in the prefrontal cortex GABA-glutamate system. J Neurochem. 99(3):892-899.
Kushnir-Sukhov, N. M., Gilfillan, A. M., Coleman, J. W., Brown, J. M., Bruening, S., Toth, M., and Metcalfe, D. D. (2006) 5-hydroxytryptamine induces mast cell adhesion and migration. J Immunol, 177:6422-6432.
Chaloupka, J.A., Bullock, S.A., Iourgenko, V., Levin, L.R., and Buck, J. (2006). Autoinhibitory regulation of soluble adenylyl cyclase. Mol. Repro & Dev. 73:361-368.
Mogenson, E.G., Janbon, G., Chaloupka, J., Steegborn, C., Fu, M.S., Moyrand, F., Klengel, T., Pearson. D.S., Geeves, M.A., Buck. J., Levin, L.R.and Muhlschlegel, F.A. (2006). Cryptococcus senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1. Eukaryotic Cell 5:103-111.
Mahurter L., Garceau C., Marino J., Schmidhammer H., Toth G., Pasternak G.W. (2006) Separation of binding affinity and intrinsic activity of the potent mu opioid 14-methoxymetopon. J Pharmacol Exp Ther. 319(1):247-253.
Gordon E., Roepke T.K., and Abbott G.W. (2006). Endogenous KCNE subunits govern Kv2.1 K+ channel activation kinetics in Xenopus oocyte studies. Biophysical Journal 90(4):1223-31.
Gordon E., Cohen J.L., Engel R., and Abbott G.W. (2006). 1,4-diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Molecular Pharmacology 69(3):718-726.
Jaggi, J. S., Seshan, S. V., McDevitt, M. R., Sgouros, G., Hyjek, E., and Scheinberg, D. A. (2006) Mitigation of radiation nephropathy after internal alpha-particle irradiation of kidneys. Int J Radiat Oncol Biol Phys, 64:1503-1512.
Gomez-Nunez, M., Pinilla-Ibarz, J., Dao, T., May, R. J., Pao, M., Jaggi, J. S., and Scheinberg, D. A. (2006) Peptide binding motif predictive algorithms correspond with experimental binding of leukemia vaccine candidate peptides to HLA-A*0201 molecules. Leuk Res, 30:1293-1298.
Wu, K.Y., Zippin, J.H., Huron, D.R., Kamenetsky M., Hengst, U., Buck, J., Levin, L.R., and Jaffrey, S.R. (2006). Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nat Neurosci. 9:1257-1264.
Stessin, A.M., Zippin, J.H., Kamenetsky M., Hess, K.C., Buck, J., and Levin, L.R. (2006). Soluble adenylyl cyclase mediates NGF-induced activation of RAP1. J. Biol. Chem. 281:17253-17258.
Pinilla-Ibarz, J., May, R. J., Korontsvit, T., Gomez, M., Kappel, B., Zakhaleva, V., Zhang, R. H., and Scheinberg, D. A. (2006) Improved human T-cell responses against synthetic HLA-0201 analog peptides derived from the WT1 oncoprotein. Leukemia, 20:2025-2033.
Kappel, B. J., Pinilla-Ibarz, J., Kochman, A. A., Eng, J. M., Hubbard, V. M., Leiner, I., Pamer, E. G., Heller, G., van den Brink, M. R., and Scheinberg, D. A. (2006) Remodeling specific immunity by use of MHC tetramers: demonstration in a graft-versus-host disease model. Blood, 107:2045-2051.
Antczak, C., Jaggi, J. S., LeFave, C. V., Curcio, M. J., McDevitt, M. R., and Scheinberg, D. A. (2006) Influence of the linker on the biodistribution and catabolism of actinium-225 self-immolative tumor-targeted isotope generators. Bioconjug Chem, 17:1551-1560.
Yun, S.W., Platholi, J., Flaherty, M.S., Fu, W., Kottmann, A.H., and Toth, M. (2006) Fmrp is required for the establishment of the startle response during the critical period of auditory development. Brain Res. 1110(1):159-65.
Moilanen, S. B.; Potuzak, J. S.; Tan, D. S. (2006) Stereocontrolled synthesis of spiroketals via a Ti(Oi-Pr)4-mediated kinetic spirocyclization of glycal epoxides with retention of configuration. J Am Chem Soc. 128:1792-1793.
Sheren-Manoff, M., Shin, S. J., Su, D., Bok, D., Rando, R. R., and Gudas, L. J. (2006) Reduced lecithin:retinol acyltransferase expression in human breast cancer. Int J Oncol, 29:1193-1199.
2005
Fan W, Bubman D, Chadburn A, Harrington WJ Jr, Cesarman E, Knowles DM. (2005) Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association. J Virol. 79(2):1244-51.
Klengel, T.*, Liang, W-J.*, Chaloupka, J.A.*, Ruoff, C.,Schroppel, K., Naglik, J.R., Eckert, S.E., Gweiss, E., Haynes, K., Tuitte, M.F., Levin, L.R., Buck, J., and Muhlschlegel, F.A. (2005). Fungal adenylyl cyclase integrates CO2 sensing with CAMP aignalling and virulence. Curr. Biol. 15:2021-2026. (*contributed to equally).
Dao, T., Gomez-Nunez, M., Antczak, C., Kappel, B., Jaggi, J. S., Korontsvit, T., Zakhaleva, V., and Scheinberg, D. A. (2005) Natural killer cells license dendritic cell cross-presentation of B lymphoma cell--associated antigens. Clin Cancer Res, 11:8763-8772.
Jaggi JS, Seshan SV, McDevitt MR, Laperle K, Sgouros G, Scheinberg DA. (2005) Renal Tubulointerstitial Changes after Internal Irradiation with {alpha}-Particle-Emitting Actinium Daughters. J Am Soc Nephrol. 16(9):2677-2689.
Jaggi JS, Kappel BJ, McDevitt MR, Sgouros G, Flombaum CD, Cabassa C and Scheinberg DA. (2005) Efforts to Control the Errant Products of a Targeted In vivo Generator. Cancer Research 65(11):4888-95.
Han H, Stessin A, Roberts J, Hess K, Gautam N, Kamenetsky M, Lou O, Hyde E, Nathan N, Muller WA, Buck J, Levin LR, Nathan C. (2005) Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. J Exp Med. 202(3):353-61.
Hess KC, Jones BH, Marquez B, Chen Y, Ord TS, Kamenetsky M, Miyamoto C, Zippin JH, Kopf GS, Suarez SS, Levin LR, Williams CJ, Buck J, Moss SB. (2005) The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell. 9(2):249-59.
Wu KY, Hengst U, Cox LJ, Macosko EZ, Jeromin A, Urquhart ER, Jaffrey SR. (2005) Local translation of RhoA regulates growth cone collapse. Nature. 436(7053):1020-4.
Potuzak, J. S.; Moilanen, S. B.; Tan, D. S. (2005) Stereocontrolled synthesis of spiroketals via a remarkable methanol-induced kinetic spirocyclization reaction. J Am Chem Soc. 127:13796-13797.
Rotolo, J.A., Zhang, J., Donepudi, M., Lee, H., Fuks, Z., Kolesnick, R. (2005) Caspase-dependent and-independent activation of acid sphingomyelinase signaling. J Biol Chem. 280(28):26425-26434.
Shang, S. and Tan, D. S. (2005) Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries. Curr Opin Chem Biol, 9:248-258.
Touma, S. E., Goldberg, J. S., Moench, P., Guo, X., Tickoo, S. K., Gudas, L. J., and Nanus, D. M. (2005) Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model. Clin Cancer Res, 11:3558-3566.
Kortmansky, J., Shah, M. A., Kaubisch, A., Weyerbacher, A., Yi, S., Tong, W., Sowers, R., Gonen, M., O'Reilly, E., Kemeny, N., Ilson, D. I., Saltz, L. B., Maki, R. G., Kelsen, D. P., and Schwartz, G. K. (2005) Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors. J Clin Oncol, 23:1875-1884.
Shah, M. A., Kortmansky, J., Motwani, M., Drobnjak, M., Gonen, M., Yi, S., Weyerbacher, A., Cordon-Cardo, C., Lefkowitz, R., Brenner, B., O'Reilly, E., Saltz, L., Tong, W., Kelsen, D. P., and Schwartz, G. K. (2005) A phase I clinical trial of the sequential combination of irinotecan followed by flavopiridol. Clin Cancer Res, 11:3836-3845.
2004
Zippin JH, Farrell J, Huron DR, Kamenetsky M, Hess KC, Fischman DA, Levin LR, Buck J. (2004) Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. J Cell Biol. 164(4):527-34.
Potuzak, J. S., Tan, D. S. (2004) Synthesis of C1-alkyl- and acylglycals from glycals using a B-alkyl Suzuki-Miyaura cross coupling approach. Tetrahedron Lett. 45:1797-1801.
Potuzak, J. S., Moilanen, S. B.; Tan, D. S. (2004) Discovery and applications of small molecule probes for studying biological processes. Biotechnol. Genet. Eng. Rev. 21:11-78.
Anantharam A., Lewis A., Panaghie G., Gordon E., McCrossan Z.A., Lerner D.J., and Abbott G.W. (2003) RNA interference reveals that endogenous Xenopus MinK-related peptides govern mammalian K+ channel function in oocyte expression studies. J Biol Chem 278:11739-45.
Huron DR, Gorre ME, Kraker AJ, Sawyers CL, Rosen N, & Moasser, MM. (2003) A Novel Pyridopyrimidine Inhibitor of Abl Kinase Is a Picomolar Inhibitor of Bcr-abl-driven K562 Cells and Is Effective against STI571-resistant Bcr-abl Mutants. Clin Cancer Res 9:1267-73.
Litvin TN, Kamenetsky M, Zarifyan A, Buck J, Levin LR. (2003) Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate. J Biol Chem 278:15922-6.
Zippin JH, Chen Y, Nahirney P, Kamenetsky M, Wuttke MS, Fischman DA, Levin LR, Buck J. (2003) Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB J 17:82-4.
McCrossan Z.A.; Lewis A.; Panaghie G.; Jordan P.N.; Christini D.J.; Lerner D.J.; Abbott GW. (2003) MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. J Neurosci. 23(22):8077-91.
2002
Birk AV, Bubman D, Broekman MJ, Robertson HD, Drosopoulos JH, Marcus AJ, Szeto HH. (2002) Role of a novel soluble nucleotide phospho-hydrolase from sheep plasma in inhibition of platelet reactivity: hemostasis, thrombosis, and vascular biology. J Lab Clin Med 139:116-24.
