PUBLICATIONS

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2008:

Veerappan A, Reid AC, Estephan R, O'Connor N, Thadani-Mulero M, Salazar-Rodriguez M, Levi R, Silver RB.  “Mast cell renin and a local renin-angiotensin system in the airway: role in bronchoconstriction.” Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1315-20. Epub 2008 Jan 17.

Machida T, Hamaya Y, Izumi S, Hamaya Y, Iizuka K, Igarashi Y, Minami M, Levi R, Hirafuji M.  “Sphingosine 1-phosphate Inhibits Nitric Oxide Production induced by Interleukin-1{beta} in Rat Vascular Smooth Muscle Cells.” J Pharmacol Exp Ther. 2008 Jan 2; [Epub ahead of print]

2007:

Kano S, Tyler E, Salazar-Rodriguez M, Estephan R, Mackins CJ, Veerappan A, Reid AC, Silver RB, Levi R.  “Immediate Hypersensitivity Elicits Renin Release from Cardiac Mast Cells.” Int Arch Allergy Immunol. 2007 Dec 14;146(1):71-75 [Epub ahead of print]

Heerdt PM, Lane P, Pan BY, Schaefer U, Crabtree M, Hong R, Singer AA, Levi R, Park BJ.  “Nitrosative stress and myocardial sarcoplasmic endoreticular calcium adenosine triphosphatase subtype 2a activity after lung resection in swine.” Anesthesiology. 2007 Dec;107(6):954-62.

Schaefer U, Machida T, Broekman MJ, Marcus AJ, Levi R.  “Targeted deletion of ectonucleoside triphosphate diphosphohydrolase 1/CD39 leads to desensitization of pre- and postsynaptic purinergic P2 receptors.” J Pharmacol Exp Ther. 2007 Sep;322(3):1269-77. Epub 2007 Jun 12.

Reid AC, Silver RB, Levi R.  “Renin: at the heart of the mast cell.” Immunol Rev. 2007 Jun;217:123-40.

Levi R, Seyedi N, Schaefer U, Estephan R, Mackins CJ, Tyler E, Silver RB.  “Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway.” Biochem Pharmacol. 2007 Apr 15;73(8):1146-56. Epub 2007 Jan 7.

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Mackins, C.J., Kano, S., Seyedi, N., Schaefer, U., Reid, A.C., Machida, T., Silver, R.B., Levi, R.: Cardiac mast-cell-derived renin promotes local angiotensin formation, norepinephrine release and arrhythmia in ischemia/reperfusion.  J. Clin. Invest., 2006.

Seyedi, N., Mackins, C.J., Machida, T., Reid, A.C., Silver, R.B. and Levi, R.: Histamine H₃-receptor-induced attenuation of norepinephrine exocytosis: A decreased PKA activity mediates a reduction in intracellular calcium. J. Pharmacol. Exp. Ther. 312: 272-280, 2005.
 
Machida, M., Heerdt, P. M., Reid, A. C., Schaefer, U., Silver, R. B., Broekman, M. J., Marcus, A. J.  and Levi, R.: E-NTPDase1/CD39, localized in neurons of human and porcine heart, modulates ATP-induced norepinephrine exocytosis. J. Pharmacol. Exp. Ther. 313: 570-577, 2005.
 
Cacheaux, L.P., Topf, N., Tibbs, G.R., Schaefer, U.R., Levi, R., Harrison, N.L., Abbott, G.W. and Goldstein, P.A.: Impairment of HCN channel function by the intravenous general anesthetic propofol. J. Pharmacol. Exp. Ther. 315: 517-525, 2005.

Silver, R.B., Reid, A.C., Mackins, C.J., Askwith, T., Schaefer, U., Herzlinger, D. and Levi, R.: Mast cells: a unique source of renin. Proc. Natl. Acad. Sci. USA 101: 13607-13612, 2004.

Matsuda, N., Jesmin, S., Takahashi,Y., Hatta, E., Kobayashi, M., Matsuyama, K., Kawakami, N., Sakuma, I., Gando, S., Fukui, H., Hattori, Y. and Levi, R. Histamine H₁- and H₂-receptor gene and protein levels are differentially expressed in the hearts of rodents and humans. J. Pharmacol. Exp. Ther. 309: 786-95, 2004.

Reid, A.C., Mackins, C.J., Seyedi, N., Levi, R. and Silver, R.B. Coupling of angiotensin II AT1 receptors to neuronal NHE activity and carrier-mediated norepinephrine release in myocardial ischemia. Am. J. Physiol. 286: H1448-H1454, 2004.

Koyama M., Heerdt P.M., Levi R. Increased severity of reperfusion arrhythmias in mouse hearts lacking histamine H3-receptors. Biochem. Biophys. Res. Commun. 306: 792-796, 2003.

Sesti C., Koyama M., Broekman M.J., Marcus A.J., Levi R. Ectonucleotidase in sympathetic nerve endings modulates ATP and norepinephrine exocytosis in myocardial ischemia. J Pharmacol Exp Ther. 306: 238-44, 2003.

Marcus A.J., Broekman M.J., Drosopoulos J.H., Islam N., Pinsky D.J., Sesti C., Levi R. Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseases. J Pharmacol Exp Ther. 305: 9-16, 2003.

Koyama M., Seyedi N., Fung-Leung W.P., Lovenberg T.W., Levi R. Norepinephrine release from the ischemic heart is greatly enhanced in mice lacking histamine H₃ receptors. Mol Pharmacol. 63: 378-82, 2003.

Silver, R.B., Poonwasi, K.S, Seyedi, N., Wilson, S.J., Lovenberg, T.W. and Levi, R. Decreased intracellular calcium mediates the histamine H₃-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings. Proc. Natl. Acad. Sci. USA 99: 501-506, 2002.

Sesti, C., Broekman, M.J., Drosopoulos, J.H.F., Islam, N., Marcus, A.J. and Levi, R. Ecto-nucleotidase in cardiac sympathetic nerve endings modulates ATP-mediated feedback of norepinephrine release. J. Pharmacol. Exp. Ther. 300: 605-611, 2002.

Seyedi, N., Koyama, M., Mackins, C.J., and Levi, R. Ischemia promotes renin activation and angiotensin formation in sympathetic nerve terminals isolated from the human heart: contribution to carrier-mediated norepinephrine release. J. Pharmacol. Exp. Ther. 302: 539-544, 2002.