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About Us
Research
Publications
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2014: |
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Aldi S, Marino A, Tomita K, Corti F, Anand R, Olson KE, Marcus AJ, Levi, R. "E-NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role." FASEB J. 2014 Oct 15. pii: fj.14-261867. Aldi S, Takano K, Tomita K, Koda K, Chan NY, Marino A, Salazar-Rodriguez M, Thurmond RL, Levi, R. "Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion via protein kinase C e-dependent aldehyde dehydrogenase type-2 activation." J Pharmacol Exp Ther. 2014 Jun;349(3):508-17. doi: 10.1124/jpet.114.214122. Epub 2014 Apr 2. Aldi S, Robador PA, Tomita K, Di Lorenzo A Levi, R. "IgE receptor-mediated mast-cell renin release"Am J Pathol. 2014 Feb;184(2):376-81. doi: 10.1016/j.ajpath.2013.10.016. Epub 2013 Nov 18.
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2012: Chan NY, Robador PA, Levi, R. "Natriuretic peptide-induced catecholamine release from cardiac sympathetic neurons: inhibition by histamine H3 and H4 receptor activation."J Pharmacol Exp Ther. 2012 Dec;343(3):568-77. doi: 10.1124/jpet.112.198747. Epub 2012 Aug 24.. Robador PA, Seyedi N, Chan NY, Koda K, Levi, R. "Aldehyde dehydrogenase type 2 activation by adenosine and histamine inhibits ischemic norepinephrine release in cardiac sympathetic neurons: mediation by protein kinase Ce"J Pharmacol Exp Ther. 2012 Oct;343(1):97-105. doi: 10.1124/jpet.112.196626. Epub 2012 Jul 3. Chan, N.Y-K., Seyedi, N.; Takano, K and Levi, R. "An Unsuspected Property of Natriuretic Peptides: Promotion of Calcium-Dependent Catecholamine Release via PKG-Mediated PDE3 Inhibition. Circulation". 2012 Jan 17;125(2):298-307.
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2011: |
Corti, F., Olson, K.E., Marcus, A.J. and Levi, R. "The expression level of E-NTPDase1/CD39 modulates exocytotic and ischemic release of neurotransmitters in a cellular model of sympathetic neurons". J. Pharmacol. Exp. Ther., 2011 May;337(2): 524-532. Reid, A.C., Brazen, J.A., Morrey, C., Silver, R.B. and Levi, R. "Targeting cardiac mast cells: Pharmacological modulation of the local renin-angiotensin system". Curr. Pharmac. Design, 2011 Nov;17(34):3744-3752.
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2010: |
Koda, K., Salazar-Rodriguez, M., Corti, F., Chan, N.Y-K., Estephan, R., Silver, R.B., Mochly-Rosen, D. and Levi, R. "Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells. Circulation". 2010 Aug;122 (8): 771-781. Morrey, C., Brazin, J., Seyedi, N., Corti, F., Silver, R.B. and Levi, R. "Interaction between Sensory C-fibers and Cardiac Mast Cells in Ischemia/Reperfusion: Activation of a Local Renin-Angiotensin System Culminating in Severe Arrhythmic Dysfunction". J. Pharmacol. Exp. Ther. 2010 Oct;335(1): 76-84. Silver RB, Reid AC, Brazin JA and Levi R. "Mast cells, local renin-angiotensin system and cardiovascular disease, in Mast Cells and Cardiovascular Disease" (Joseph J. ed.), Nova Science Publishers, Inc., New York, 2010, pp 5-32.
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2008: |
Morrey, C., Estephan, R., Abbott, G.W. and Levi, R. Cardioprotective Effect of histamine H3-receptor activation: pivotal role of G?y-dependent inhibition of voltage-operated Ca2+ channels. J. Pharmacol. Exp. Ther., 2008 Sept;326(3): 871-878. Kano, S., Tyler, E., Salazar-Rodriguez, M., Estephan, R., Mackins, C.J., Veerappan, A., Reid, A.C., Silver, R.B. and Levi, R. “Immediate hypersensitivity elicits renin release from cardiac mast cells.” Intl. Arch. Allergy Immunol. 2008;146(1): 71-75. Veerappan A, Reid AC, Estephan R, O'Connor N, Thadani-Mulero M, Salazar-Rodriguez M, Levi R, Silver RB. “Mast cell renin and a local renin-angiotensin system in the airway: role in bronchoconstriction.” Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1315-20. Epub 2008 Jan 17. Machida T, Hamaya Y, Izumi S, Hamaya Y, Iizuka K, Igarashi Y, Minami M, Levi R, Hirafuji M. “Sphingosine 1-phosphate Inhibits Nitric Oxide Production induced by Interleukin-1{beta} in Rat Vascular Smooth Muscle Cells.” J Pharmacol Exp Ther. 2008 Jan 2; [Epub ahead of print]
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2007: |
Kano S, Tyler E, Salazar-Rodriguez M, Estephan R, Mackins CJ, Veerappan A, Reid AC, Silver RB, Levi R. “Immediate Hypersensitivity Elicits Renin Release from Cardiac Mast Cells.” Int Arch Allergy Immunol. 2007 Dec 14;146(1):71-75 [Epub ahead of print] Heerdt PM, Lane P, Pan BY, Schaefer U, Crabtree M, Hong R, Singer AA, Levi R, Park BJ. “Nitrosative stress and myocardial sarcoplasmic endoreticular calcium adenosine triphosphatase subtype 2a activity after lung resection in swine.” Anesthesiology. 2007 Dec;107(6):954-62. Schaefer U, Machida T, Broekman MJ, Marcus AJ, Levi R. “Targeted deletion of ectonucleoside triphosphate diphosphohydrolase 1/CD39 leads to desensitization of pre- and postsynaptic purinergic P2 receptors.” J Pharmacol Exp Ther. 2007 Sep;322(3):1269-77. Epub 2007 Jun 12. Reid AC, Silver RB, Levi R. “Renin: at the heart of the mast cell.” Immunol Rev. 2007 Jun;217:123-40. Levi R, Seyedi N, Schaefer U, Estephan R, Mackins CJ, Tyler E, Silver RB. “Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway.” Biochem Pharmacol. 2007 Apr 15;73(8):1146-56. Epub 2007 Jan 7.
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OTHER: Mackins, C.J.,
Kano, S., Seyedi, N., Schaefer, U., Reid, A.C., Machida, T., Silver, R.B., Levi, R.: Cardiac mast-cell-derived renin promotes local angiotensin
formation, norepinephrine release and arrhythmia in ischemia/reperfusion. J. Clin. Invest., 2006. Silver, R.B., Reid, A.C., Mackins, C.J., Askwith, T., Schaefer, U., Herzlinger, D. and Levi, R.: Mast cells: a unique source of renin. Proc. Natl. Acad. Sci. USA 101: 13607-13612, 2004. Matsuda, N., Jesmin, S., Takahashi,Y., Hatta, E., Kobayashi, M., Matsuyama, K., Kawakami, N., Sakuma, I., Gando, S., Fukui, H., Hattori, Y. and Levi, R. Histamine H1- and H2-receptor gene and protein levels are differentially expressed in the hearts of rodents and humans. J. Pharmacol. Exp. Ther. 309: 786-95, 2004. Reid, A.C., Mackins, C.J., Seyedi, N., Levi, R. and Silver, R.B. Coupling of angiotensin II AT1 receptors to neuronal NHE activity and carrier-mediated norepinephrine release in myocardial ischemia. Am. J. Physiol. 286: H1448-H1454, 2004. Koyama M., Heerdt P.M., Levi R. Increased severity of reperfusion arrhythmias in mouse hearts lacking histamine H3-receptors. Biochem. Biophys. Res. Commun. 306: 792-796, 2003. Sesti C., Koyama M., Broekman M.J., Marcus A.J., Levi R. Ectonucleotidase in sympathetic nerve endings modulates ATP and norepinephrine exocytosis in myocardial ischemia. J Pharmacol Exp Ther. 306: 238-44, 2003. Marcus A.J., Broekman M.J., Drosopoulos J.H., Islam N., Pinsky D.J., Sesti C., Levi R. Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseases. J Pharmacol Exp Ther. 305: 9-16, 2003. Koyama M., Seyedi N., Fung-Leung W.P., Lovenberg T.W., Levi R. Norepinephrine release from the ischemic heart is greatly enhanced in mice lacking histamine H3 receptors. Mol Pharmacol. 63: 378-82, 2003. Silver, R.B., Poonwasi, K.S, Seyedi, N., Wilson, S.J., Lovenberg, T.W. and Levi, R. Decreased intracellular calcium mediates the histamine H3-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings. Proc. Natl. Acad. Sci. USA 99: 501-506, 2002. Sesti, C., Broekman, M.J., Drosopoulos, J.H.F., Islam, N., Marcus, A.J. and Levi, R. Ecto-nucleotidase in cardiac sympathetic nerve endings modulates ATP-mediated feedback of norepinephrine release. J. Pharmacol. Exp. Ther. 300: 605-611, 2002. Seyedi, N., Koyama, M., Mackins, C.J., and Levi, R. Ischemia promotes renin activation and angiotensin formation in sympathetic nerve terminals isolated from the human heart: contribution to carrier-mediated norepinephrine release. J. Pharmacol. Exp. Ther. 302: 539-544, 2002. |
