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         Diani-Moore S, Ma Y, Gross SS, Rifkind, A.B..Increases in levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (EETs and DHETs) in liver and heart in vivo by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in hepatic EET:DHET ratios by cotreatment with TCDD and the soluble epoxide hydrolase inhibitor AUDA. Drug Metab Dispos. 2014 Feb;42(2):294-300. doi: 10.1124/dmd.113.055368. Epub 2013 Dec 5..

         Diani-Moore S, Zhang S, Ram P, Rifkind, A.B.. Aryl hydrocarbon receptor activation by dioxin targets phosphoenolpyruvate carboxykinase (PEPCK) for ADP-ribosylation via 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP). J Biol Chem. 2013 Jul 26;288(30):21514-25. doi: 10.1074/jbc.M113.458067. Epub 2013 Jun 14.

         Rifkind, A.B..Competing interests: Expanding rapidly. Nature. 2012 Aug 30;488(7413):590. doi: 10.1038/488590b..

         Diani-Moore S, Ram P, Li X, Mondal P, Youn DY, Sauve AA, Rifkind, A.B.. Discovery and biological characterization of 1-(1H-indol-3-yl)-9H-pyrido[3,4-b]indole as an aryl hydrocarbon receptor activator generated by photoactivation of tryptophan by sunlight. Chem Biol Interact. 2011 Sep 5;193(2):119-28. doi: 10.1016/j.cbi.2011.05.010. Epub 2011 Jun 22..

         Diani-Moore S, Ram P, Li X, Mondal P, Youn DY, Sauve AA, Rifkind, A.B.. Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect. J Biol Chem. 2010 Dec 10;285(50):38801-10. doi: 10.1074/jbc.M110.131573. Epub 2010 Sep 28.

         Nair S, Kekatpure VD, Judson BL, Rifkind, A.B., Granstein RD, Boyle J, Subbaramaiah K, Guttenplan JB, Dannenberg AJ. UVR exposure sensitizes keratinocytes to DNA adduct formation. Cancer Prev Res (Phila). 2009 Oct;2(10):895-902. doi: 10.1158/1940-6207.CAPR-09-0125. Epub 2009 Sep 29..

         Labitzke, EM, Diani-Moore, S., and Rifkind, A.B. Mitochondrial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase. Arch. Biochem. Biophys. 2007- published on-line doi:10.1016/j.abb.2007.08.012.

         Diani-Moore, S.  Papachristou, F., Labitzke, E. and Rifkind, A.B. Induction of CYP1A and CYP2 mediated arachidonic acid epoxygenation and suppression of 20-HETE by imidazole derivatives including the aromatase inhibitor vorozole. Drug Metab. Disp. 34: 1376-1385, 2006. 

         Rifkind, A.B. CYP1A in TCDD toxicity and in physiology with particular reference to CYP dependent arachidonic acid metabolism and other endogenous substrates. Drug Metab. Rev., 38, 291-335, 2006.

         Diani-Moore, S., Labitzke, E,  Brown, R., Garvin, A., Wong, L and Rifkind, A.B. Sunlight generates multiple tryptophan photoproducts eliciting high efficacy CYP1A induction in chick hepatocytes and in vivo, Toxicol.. Sci.  90: 96-110, 2006

         Wood, E., Broekman, M.J., Kirley, T., Diani-Moore, S., Tickner, M., Drosopoulis, J., Islam, N., Park, J., Marcus, A., and Rifkind, A.B. Cell-type specificity of ectonucleotidase expression and upregulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.  Arch. Biochem. Biophys. 407: 49-62, 2002.

         Fan, L., Ovadia, M., Freidman, D.M. and Rifkind, A.B. Ventricular preexcitation sensitive to flecainide in late stage chick embryo ECGs: 2,3,7,8-Tetrachlorodibenzo-p-dioxin impairs inotropic but not chronotropic or dromotropic responses to isoproterenol and confers resistance to flecainide. Toxicol. Appl. Pharmacol. 166: 43-50, 2000.

         Mahajan, S.S. and Rifkind, A.B. Transcriptional activation of avian CYP1A4 and CYP1A5 by 2,3,7,8 -Tetrachlorodibenzo-p-dioxin: Differences in gene expression and regulation compared to mammalian CYP1A1 and CYP1A2. Toxicol. Appl. Pharmacol. 155: 96-206, 1999.

         Gannon, M., Gilday, D. and Rifkind, A.B. TCDD induces CYP1A4 and CYP1A5 in chick liver and kidney and only CYP1A4 , an enzyme lacking arachidonic acid epoxygenase activity, in myocardium and vascular endothelium. Toxicol. Appl. Pharmacol. 164: 24-37, 1999.

         Lee, C.A., Lawrence, B.P., Kerkvliet, N.I. and Rifkind, A.B. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induction of cytochrome P450 dependent arachidonic acid metabolism in mouse liver microsomes; evidence for species specific differences in responses. Toxicol. Appl. Pharmacol. 153: 1-11, 1998.

         Gilday, D., Gannon, M., Yutzey, K., Bader, D., and Rifkind, A.B. Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin. J. Biol. Chem. 271: 33054-33059, 1996.

         Canga, L., Paroli, L., Blanck, T.J.J., Silver, R.B. and Rifkind, A.B. 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases cardiac myocyte intracellular calcium and progressively impairs ventricular contractile responses to isoproterenol and to calcium in chick embryo hearts.  Molec Pharmacol  44:1142-1151, 1993.


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