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• Cerutti R, Pirinen E, Lamperti C, Marchet S, Sauve AA, Li W, Leoni V, Schon EA, Dantzer F, Auwerx J, Viscomi C, Zeviani M NAD(+)-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease. Cell Metab. 2014 Jun 3;19(6):1042-9. doi: 10.1016/j.cmet.2014.04.001. Epub 2014 May 8.
  PMID:24814483

• Pirinen E, Cant, Jo YS, Morato L, Zhang H, Menzies KJ, Williams EG, Mouchiroud L, Moullan N, Hagberg C, Li W, Timmers S, Imhof R, Verbeek J, Pujol A, van Loon B, Viscomi C, Zeviani M, Schrauwen P, Sauve AA, Schoonjans K, Auwerx J Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. Cell Metab. 2014 Jun 3;19(6):1034-41. doi: 10.1016/j.cmet.2014.04.002. Epub 2014 May 8.
  PMID:24814482

• Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB, Schoonjans K, Auwerx J Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014 Apr 10;508(7495):258-62. doi: 10.1038/nature13198.
  PMID:24717514

• Lim J, Liu Z, Apontes P, Feng D, Pessin JE, Sauve AA, Angeletti RH, Chi Y. Dual mode action of mangiferin in mouse liver under high fat diet.. PLoS One. 2014 Mar 5;9(3):e90137. doi: 10.1371/journal.pone.0090137. eCollection 2014.
  PMID:24598864

• Canto C, Sauve AA, Bai P. Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. Mol Aspects Med. 2013 Dec;34(6):1168-201. doi: 10.1016/j.mam.2013.01.004. Epub 2013 Jan 25.
  PMID:23357756

• Chi Y, Sauve AA Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):657-61. doi: 10.1097/MCO.0b013e32836510c0.
  PMID:24071780

• Laurent G, de Boer VC, Finley LW, Sweeney M, Lu H, Schug TT, Cen Y, Jeong SM, Li X, Sauve AA, Haigis MC, Bai P. SIRT4 represses peroxisome proliferator-activated receptor a activity to suppress hepatic fat oxidation. Mol Cell Biol. 2013 Nov;33(22):4552-61. doi: 10.1128/MCB.00087-13. Epub 2013 Sep 16.
  PMID:24043310

• Langley B, Sauve AA Sirtuin deacetylases as therapeutic targets in the nervous system. Neurotherapeutics. 2013 Oct;10(4):605-20. doi: 10.1007/s13311-013-0214-5.
  PMID:24037427

• Gong B, Pan Y, Vempati P, Zhao W, Knable L, Ho L, Wang J, Sastre M, Ono K, Sauve AA, Pasinetti GM. Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-y coactivator 1a regulated b-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models Neurobiol Aging. 2013 June; 34(6): 1581?1588. Published online 2013 January 9. doi: 10.1016/j.neurobiolaging.2012.12.005.
  PMID: 23312803

• Sauve AA, Youn DY. Sirtuins: NAD(+)-dependent deacetylase mechanism and regulationCurr Opin Chem Biol. 2012 Dec;16(5-6):535-43. doi: 10.1016/j.cbpa.2012.10.003. Epub 2012 Oct 23.
  PMID:23102634

• Canto C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity Cell Metab. 2012 Jun 6;15(6):838-47. doi: 10.1016/j.cmet.2012.04.022.
  PMID: 22682224

• Bai P, Canto C, Oudart H, Brunyanszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, Schoonjans K, Schreiber V, Sauve AA, Menissier-de Murcia J, Auwerx J. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab. 2011 Apr 6;13(4):461-8. doi: 10.1016/j.cmet.2011.03.004.
  PMID: 21459330

• Bai P, Canto C, Brunyanszki A, Huber A, Szanto M, Cen Y, Yamamoto H, Houten SM, Kiss B, Oudart H, Gergely P, Menissier-de Murcia J, Schreiber V, Sauve AA, Auwerx J. PARP-2 regulates SIRT1 expression and whole-body energy expenditure Cell Metab. 2011 Apr 6;13(4):450-60. doi: 10.1016/j.cmet.2011.03.013.
  PMID:21459329

• Cen Y, Falco JN, Xu P, Youn DY, Sauve AA Mechanism-based affinity capture of sirtuins Org Biomol Chem. 2011 Feb 21;9(4):987-93. doi: 10.1039/c0ob00774a. Epub 2010 Dec 24.
  PMID: 21184005

• Cen Y, Youn DY, Sauve AA Advances in characterization of human sirtuin isoforms: chemistries, targets and therapeutic applications. Curr Med Chem. 2011;18(13):1919-35.
  PMID:21517779

• French JB, Cen Y, Vrablik TL, Xu P, Allen E, Hanna-Rose WSauve AA Characterization of nicotinamidases: steady state kinetic parameters, classwide inhibition by nicotinaldehydes, and catalytic mechanism. Biochemistry. 2010 Dec 14;49(49):10421-39. doi: 10.1021/bi1012518. Epub 2010 Nov 15.
  PMID: 20979384

• Diani-Moore S1, Ram P, Li X, Mondal P, Youn DY, Sauve AA Rifkind AB. Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect. J Biol Chem. 2010 Dec 10;285(50):38801-10. doi: 10.1074/jbc.M110.131573. Epub 2010 Sep 28.
  PMID:20876576

• French JB, Cen Y,Sauve AA, Ealick SE. High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes . Biochemistry. 2010 Oct 12;49(40):8803-12. doi: 10.1021/bi1012436. Epub 2010 Sep 20
  PMID:20853856

• Cen Y, Sauve AA Transition state of ADP-ribosylation of acetyllysine catalyzed by Archaeoglobus fulgidus Sir2 determined by kinetic isotope effects and computational approaches. J Am Chem Soc. 2010 Sep 8;132(35):12286-98. doi: 10.1021/ja910342d.
  PMID:20718419

• Sauve AA Sirtuin chemical mechanisms. Biochim Biophys Acta. 2010 Aug;1804(8):1591-603. doi: 10.1016/j.bbapap.2010.01.021. Epub 2010 Feb 2.
  PMID: 20132909

• Xu P, Sauve AA Vitamin B3, the nicotinamide adenine dinucleotides and aging Mech Ageing Dev. 2010 Apr;131(4):287-98. doi: 10.1016/j.mad.2010.03.006. Epub 2010 Mar 20.
  PMID: 20307564

• Gainsford GJ, Furneaux RH, Tyler PC, Sauve AA, Shramm VL. A synchrotron radiation study of the one-dimensional complex of sodium with (1S)-N-carboxylato-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol, a member of the 'immucillin' family Cell Metab. 2011 Apr 6;13(4):450-60. doi: 10.1016/j.cmet.2011.03.013.
  PMID:20203397

• Cen Y, Sauve AA Efficient syntheses of clofarabine and gemcitabine from 2-deoxyribonolactone. Nucleosides Nucleotides Nucleic Acids. 2010 Feb;29(2):113-22. doi: 10.1080/15257771003597758.
  PMID: 20391198

• Frizzell KM1, Gamble MJ, Berrocal JG, Zhang T, Krishnakumar R, Cen Y,Sauve AA, Kraus WL. Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells. J Biol Chem. 2009 Dec 4;284(49):33926-38. doi: 10.1074/jbc.M109.023879. Epub 2009 Oct 7..
  PMID: 19812418

• Cen Y, Sauve AA Diastereocontrolled electrophilic fluorinations of 2-deoxyribonolactone: syntheses of all corresponding 2-deoxy-2-fluorolactones and 2'-deoxy-2'-fluoro-NAD+s. J Org Chem. 2009 Aug 21;74(16):5779-89. doi: 10.1021/jo900637f.
  PMID: 19958035

• Sauve AA Pharmaceutical strategies for activating sirtuins. Curr Pharm Des. 2009;15(1):45-56
  PMID: 19149602

• Zhang T, Berrocal JG, Frizzell KM, Gamble MJ, DuMond ME, Krishnakumar R, Yang T, Sauve AA, Kraus WL. Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters. J Biol Chem. 2009 Jul 24;284(30):20408-17. doi: 10.1074/jbc.M109.016469. Epub 2009 May 28.
  PMID: 19478080

• French JB, Cen Y,Sauve AA Plasmodium falciparum Sir2 is an NAD+-dependent deacetylase and an acetyllysine-dependent and acetyllysine-independent NAD+ glycohydrolase. Biochemistry. 2008 Sep 23;47(38):10227-39. doi: 10.1021/bi800767t. Epub 2008 Aug 26.
  PMID: 18729382

• Sauve AA, A SIR-tain acetyl complex is caught by a sulfur trap. Structure. 2008 Sep 10;16(9):1289-92. doi: 10.1016/j.str.2008.08.004..
  PMID: 18786390

• Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, Sartorelli V. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell. 2008 May;14(5):661-73.
  PMID: 18477450

• Sauve AA.  NAD+ and vitamin B3: from metabolism to therapies. J Pharmacol Exp Ther. 2008 Mar;324(3):883-93. Epub 2007 Dec 28. Review.
  PMID: 18165311

• Yang T, Chan NY, Sauve AA.  Syntheses of nicotinamide riboside and derivatives: effective agents for increasing nicotinamide adenine dinucleotide concentrations in mammalian cells. J Med Chem. 2007 Dec 27;50(26):6458-61. Epub 2007 Dec 6.
  PMID: 18052316

• Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C.   Nicotinamide riboside kinase structures reveal new pathways to NAD+. PLoS Biol. 2007 Oct 2;5(10):e263.
  PMID: 17914902

• Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA.  Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell. 2007 Sep 21;130(6):1095-107.
  PMID: 17889652

• Fu M, Liu M, Sauve AA, Jiao X, Zhang X, Wu X, Powell MJ, Yang T, Gu W, Avantaggiati ML, Pattabiraman N, Pestell TG, Wang F, Quong AA, Wang C, Pestell RG. Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol. 2006 Nov;26(21):8122-35. Epub 2006 Aug 21.
  PMID: 16923962

• Yang T, Sauve AA. NAD metabolism and sirtuins: Metabolic regulation of protein deacetylation in stress and toxicity. AAPS J. 2006 Oct 6;8(4):E632-43. Review.
  PMID: 17233528

   

• Qin W, Yang T, Ho L, Zhao J, Chen L, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimers disease amyloid neuropathology by calorie restriction. J Biol Chem. 2006 Aug 4;281(31):21745-54. Epub 2006 Jun 2.
  PMID: 16751189

• Sauve AA, Wolberger C, Schramm VL, Boeke J. The Biochemsitry of Sirtuins. Annu Rev Biochem. 2006;75:435-65. Review.
  PMID: 16756498

• Yang T, Fu M, Pestell R, Sauve AA. SIRT1 and Endocrine Signaling. Trends Endocrinol Metab. 2006 Jul;17(5):186-91. Epub 2006 May 8. Review.
  PMID: 16684606

• Sauve AA, Moir RD, Schramm VL, Willis IM. Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition. Mol Cell., 2005, 17(4):595-601.

PMID: 15721262

• Bouras T, Fu M, Sauve AA, Wang F, Quong AA, Perkins ND, Hay RT, Gu W, Pestell RG. SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell-cycle regulatory domain 1. J. Biol. Chem. 2005, 280(11):10264-76.

PMID: 15632193

 

• Sauve AA, Schramm VL. Sir2: The biochemical mechanism of NAD+-dependent protein deacetylation and ADP-ribosyl enzyme intermediates. Curr. Med. Chem. 2004, 11:807-826.

• Sauve AA, Schramm VL. Sir2 regulation by nicotinamde results from switching between base exchange and deacetylation chemistry. Biochemistry 2003, 42(31):9249-9256.

• Sauve AA, Schramm VL. Mechanism-based inhibitors of CD38: A mammalian ADP-ribosylcyclase. Biochemistry 2002, 41:8455-8463.

• Sauve AA, Celic I, Avalos J, Deng HT, Boeke J, Schramm VL. Chemistry of gene silencing: The mechanism of NAD+-dependent deacetylation reactions. Biochemistry 2001, 40(51); 15456-15463.

• Sauve AA, Deng HT, Angelletti R, Schramm VL. A covalent intermediate in CD38 is responsible for ADP-ribosylation reactions. J. Amer. Chem. Soc. 2000, 122:7855-7859.

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